MOLECULAR ASSOCIATION OF THE NEURAL ADHESION MOLECULES L1 AND N-CAM IN THE SURFACE-MEMBRANE OF NEUROBLASTOMA-CELLS IS SHOWN BY CHEMICAL CROSS-LINKING

被引：22

作者：

SIMON, H ^{[1
]}

KLINZ, S ^{[1
]}

FAHRIG, T ^{[1
]}

SCHACHNER, M ^{[1
]}

机构：

[1] UNIV HEIDELBERG,DEPT NEUROBIOL,W-6900 HEIDELBERG 1,GERMANY

来源：

EUROPEAN JOURNAL OF NEUROSCIENCE | 1991年 / 3卷 / 07期

关键词：

L1; N-CAM; ADHESION MOLECULE; MOUSE; NERVOUS SYSTEM; CROSS-LINKING;

D O I：

10.1111/j.1460-9568.1991.tb00849.x

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The two neural cell adhesion molecules Ll and N-CAM could be shown to be associated in the surface membrane of cultured neuroblastoma cells by chemical cross-linking with 3,3'-dithiobis(sulphosuccinimidyl-propionate) and subsequent immunopurification and precipitation using antibodies to Ll and N-CAM. Glycoproteins recognized in neuroblastoma cells by antibodies to mouse liver membranes were not chemically cross-linked to Ll or N-CAM. These observations suggest that a molecular association between the two molecules may be the basis for their functional cooperativity (Kadmon et al., 1990a,b, J. Cell Biol., 110,193-208;209-218).

引用

页码：634 / 640

页数：7

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