MODELING OF DRUG RELEASE FROM PELLETS COATED WITH AN INSOLUBLE POLYMERIC MEMBRANE

被引：19

作者：

HUSSON, I ^{[1
]}

LECLERC, B ^{[1
]}

SPENLEHAUER, G ^{[1
]}

VEILLARD, M ^{[1
]}

COUARRAZE, G ^{[1
]}

机构：

[1] UNIV PARIS SUD,CTR ETUD PHARMACEUT,PHYS PHARMACEUT LAB,CNRS,URA 1218,5 RUE JEAN BAPTISTE CLEMENT,F-92296 CHATENAY MALABRY,FRANCE

来源：

JOURNAL OF CONTROLLED RELEASE | 1991年 / 17卷 / 02期

关键词：

MODELING; COATED PELLET; DIFFUSION; ACRYLIC COPOLYMER; ORAL CONTROLLED RELEASE;

D O I：

10.1016/0168-3659(91)90056-J

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

In this work, a model is proposed to accurately describe drug release kinetics from coated pellets where the membrane does not entirely control the release. To validate the model, ketoprofen pellets prepared using the extrusion-spheronisation process, were coated with a membrane comprising acrylic resins (either 100% Eudragit RL or 50% Eudragit RL and 50% Eudragit RS) and different plasticizers. The effect of the membrane composition on drug release from coated pellets was investigated using the USP dissolution paddle method. In addition, permeation kinetics through free films made with the coating polymers were performed. The model permitted to quantitatively correlate the release kinetics from coated pellets with the permeation properties of free films by taking into account the physical parameters of the systems. The advantage of this model is the possibility of ab initio optimization, from easy experiments not including coated pellets: drug release from uncoated matrices and permeation kinetics through free films.

引用

页码：163 / 173

页数：11

共 11 条

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