Interactions between the immune system and bone

被引:8
作者
D'Amelio, Patrizia [1 ]
Fornelli, Giorgia [1 ]
Roato, Ilaria [2 ]
Isaia, Giovanni Carlo [1 ]
机构
[1] Univ Torino, Dept Surg & Med Disciplines, Sect Gerontol, Corso Bramante 88-90, I-10126 Turin, Italy
[2] San Giovanni Battista Hosp, Ctr Res & Med Studies & Polo Oncol, I-10126 Turin, Italy
关键词
Osteoclast; T cells; Cytokines; Osteoporosis; Immune system; Menopause;
D O I
10.5312/wjo.v2.i3.25
中图分类号
R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学(修复外科学)];
学科分类号
摘要
The relationship between the immune system, estrogen deficiency and bone loss is an intriguing and, as yet, unexplained challenge of the past two decades. Here we summarize the evidence that links immune cells, inflammation, cytokine production and osteoclast formation and activity with particular regard to humans. (C) 2011 Baishideng. All rights reserved.
引用
收藏
页码:25 / 30
页数:6
相关论文
共 72 条
[1]   17β-estradiol inhibits class II major histocompatibility complex (MHC) expression:: Influence on histone modifications and CBP recruitment to the class II MHC promoter [J].
Adamski, J ;
Ma, ZD ;
Nozell, S ;
Benveniste, EN .
MOLECULAR ENDOCRINOLOGY, 2004, 18 (08) :1963-1974
[2]   Dendritic Cells: A New Player in Osteoimmunology [J].
Alnaeeli, M. ;
Teng, Y. -T. A. .
CURRENT MOLECULAR MEDICINE, 2009, 9 (07) :893-910
[3]   Dendritic cells at the osteo-immune interface: Implications for inflammation-induced bone loss [J].
Alnaeeli, Mawadda ;
Park, Jaekweon ;
Mahamed, Deeqa ;
Penninger, Joseph M. ;
Teng, Yen-Tung A. .
JOURNAL OF BONE AND MINERAL RESEARCH, 2007, 22 (06) :775-780
[4]   Estradiol repression of tumor necrosis factor-α transcription requires estrogen receptor activation function-2 and is enhanced by coactivators [J].
An, JP ;
Ribeiro, RCJ ;
Webb, P ;
Gustafsson, JÅ ;
Kushner, PJ ;
Baxter, JD ;
Leitman, DC .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (26) :15161-15166
[5]  
ARNOLDI J, 1990, AM J PATHOL, V137, P749
[6]   T cells support osteoclastogenesis in an in vitro model derived prom human periodontitis patients [J].
Brunetti, G ;
Colucci, S ;
Pignataro, P ;
Coricciati, M ;
Mori, G ;
Cirulli, N ;
Zallone, A ;
Grassi, FR ;
Grano, M .
JOURNAL OF PERIODONTOLOGY, 2005, 76 (10) :1675-1680
[7]   DOUBLE-BLIND TRIAL OF RECOMBINANT GAMMA-INTERFERON VERSUS PLACEBO IN THE TREATMENT OF RHEUMATOID-ARTHRITIS [J].
CANNON, GW ;
PINCUS, SH ;
EMKEY, RD ;
DENES, A ;
COHEN, SA ;
WOLFE, F ;
SAWAY, PA ;
JAFFER, AM ;
WEAVER, AL ;
COGEN, L ;
SCHINDLER, JD .
ARTHRITIS AND RHEUMATISM, 1989, 32 (08) :964-973
[8]   Estrogen deficiency induces bone loss by increasing T cell proliferation and lifespan through IFN-γ-induced class II transactivator [J].
Cenci, S ;
Toraldo, G ;
Weitzmann, MN ;
Roggia, C ;
Gao, YH ;
Qian, WP ;
Sierra, O ;
Pacifici, R .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (18) :10405-10410
[9]   Effect of blockade of TNF-α and interleukin-1 action on bone resorption in early postmenopausal women [J].
Charatcharoenwitthaya, Natthinee ;
Khosla, Sundeep ;
Atkinson, Elizabeth J. ;
McCready, Louise K. ;
Riggs, B. Lawrence .
JOURNAL OF BONE AND MINERAL RESEARCH, 2007, 22 (05) :724-729
[10]   CD16 (FcRγIII) as a potential marker of osteoclast precursors in psoriatic arthritis [J].
Chiu, Yahui Grace ;
Shao, Tianmeng ;
Feng, Changyong ;
Mensah, Kofi A. ;
Thullen, Michael ;
Schwarz, Edward M. ;
Ritchlin, Christopher T. .
ARTHRITIS RESEARCH & THERAPY, 2010, 12 (01)