METABOLIC EFFECTS OF CARBOCALCITONIN AND SALMON-CALCITONIN, AFTER ENDONASAL ADMINISTRATION IN MAN

被引：1

作者：

CECCHETTIN, M ^{[1
]}

SEGRE, G ^{[1
]}

机构：

[1] UNIV SIENA,CTR CLIN PHARMACOL PHARMATOXICOL & MED THERAPY,PHARMACOKINET LAB,I-53100 SIENA,ITALY

来源：

BIOMEDICINE & PHARMACOTHERAPY | 1995年 / 49卷 / 04期

关键词：

CARBOCALCITONIN ADMINISTRATION; SALMON CALCITONIN; ENDONASAL;

D O I：

10.1016/0753-3322(96)82622-9

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

This study evaluates the biological effects caused in healthy males by administration by the endonasal route of 50 IU and 100 IU of salmon calcitonin and 40 IU of carbocalcitonin or (Asu 1.7 eCT), an aminosuberic analogue of eel calcitonin. The comparison among calcitonins administred shows an absorption of carbocalcitonin greater than 50%, still measurable al 240th minute, while the absorptions of salmon calcitonin are shorter. The efficacy of absorption of carbocalcitonin is demonstrated by the magnitude of the biological effects such as decrease of total serum calcium and increase of cAMP.

引用

页码：215 / 218

页数：4

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