THE NONSPECIFIC NATURE OF ENDOTOXIN TOLERANCE

被引：96

作者：

CAVAILLON, JM ^{[1
]}

机构：

[1] INST PASTEUR,UNITE IMMUNOALLERGIE,F-75015 PARIS,FRANCE

来源：

TRENDS IN MICROBIOLOGY | 1995年 / 3卷 / 08期

关键词：

D O I：

10.1016/S0966-842X(00)88963-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Re-exposure of organisms or cells to endotoxin after a previous challenge is not accompanied by the profound metabolic changes that are induced by the first encounter with endotoxin. Endotoxin tolerance is not specific to the action of lipopolysaccharide, and crossreactivity with other exogenous stimuli occurs. Various cytokines can mimic the effects of endotoxin in vivo and/or in vitro.

引用

页码：320 / 324

页数：5

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