A HUMAN ALPHA-FETOPROTEIN ENHANCER-BINDING PROTEIN, ATBF1, CONTAINS 4 HOMEODOMAINS AND 17 ZINC FINGERS

被引：133
作者：
MORINAGA, T
YASUDA, H
HASHIMOTO, T
HIGASHIO, K
TAMAOKI, T
机构：
[1] UNIV CALGARY,FAC MED,DEPT MED BIOCHEM,CALGARY T2N 4N1,ALBERTA,CANADA
[2] HYOGO MED UNIV,DEPT GENET,NISHINOMIYA,HYOGO 663,JAPAN
来源：
MOLECULAR AND CELLULAR BIOLOGY | 1991年 / 11卷 / 12期
关键词：
D O I：
10.1128/MCB.11.12.6041
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
We have isolated a full-length cDNA encoding a protein (ATBF1) that binds to an AT-rich motif in the human alpha-fetoprotein gene enhancer. The amino acid sequence deduced from the cDNA revealed that this is the largest DNA-binding protein (306 kDa) known to date, containing four homeodomains, 17 zinc finger motifs, and a number of segments potentially involved in transcriptional regulation. Although the exact function of this protein has not been determined, these structural features suggest that ATBF1 plays a transcriptional regulatory role.
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页码：6041 / 6049
页数：9
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