SYNTHESIS FROM A HEPTONOLACTONE AND EFFECT ON GLYCOSIDASES OF (1S,2R,6R,7S)-1,2,6,7-TETRAHYDROXYPYRROLIZIDINE

被引：29
作者：
FAIRBANKS, AJ
FLEET, GWJ
JONES, AH
BRUCE, I
ALDAHER, S
DIBELLO, IC
WINCHESTER, B
机构：
[1] DYSON PERRINS LAB,S PARKS RD,OXFORD OX1 3QY,ENGLAND
[2] INST CHILD HLTH,DEPT CLIN BIOCHEM,LONDON WC1N 1EH,ENGLAND
[3] OXFORD CTR MOLEC SCI,OXFORD OX1 3QY,ENGLAND
来源：
TETRAHEDRON | 1991年 / 47卷 / 01期
关键词：
D O I：
10.1016/0040-4020(91)80015-T
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A five step synthesis of the pseudo C2 symmetric (1S,2R,6R,7S)-1,2,6,7-tetrahydroxypyrrolizidine from 2,3:5,6-di-O-isopropylidene-D-glycero-D-talo-heptono-1,4-lactone is reported. The effects of structure of some polyhydroxylated pyrrolizidines and pyrrolidines on inhibition of mannosidases are compared. © 1991.
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页码：131 / 138
页数：8
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