O-6-ALKYLTRANSFERASE ACTIVITY IN NORMAL HUMAN GASTRIC-MUCOSA

被引：7

作者：

DYKE, GW

CRAVEN, JL

HALL, R

COOPER, DP

SOBALLA, G

GARNER, RC

机构：

[1] GEN INFIRM,LEEDS LS1 3EX,W YORKSHIRE,ENGLAND

[2] YORK DIST GEN HOSP,YORK YO3 7HE,N YORKSHIRE,ENGLAND

[3] CHRISTIE HOSP & HOLT RADIUM INST,PATERSON INST CANC RES,MANCHESTER M20 9BX,LANCS,ENGLAND

来源：

CANCER LETTERS | 1990年 / 54卷 / 03期

关键词：

alkyltransferase; DNA repair; gastric mucosa;

D O I：

10.1016/0304-3835(90)90036-W

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The spectrum of activity of the DNA repair enzyme O6-alkyltransferase has been studied in a large series of normal stomachs in order to establish the baseline range of values for this enzyme. Sixty-eight patients with histologically normal stomachs were biopsied during the course of upper gastrointestinal endoscopy and the biopsies assayed for O6-alkyl-transferase activity. A wide spectrum of activity was found with values ranging from 38 fmol O6-guanine extracted/mg protein to over 400 fmol/mg. This suggests that there may be wide interindividual differences in susceptibility to alkylating actions in the human gastric mucosa. © 1990.

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页码：147 / 151

页数：5

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