CIRCULATING LEVELS OF PREGNANCY PROTEINS IN EARLY AND LATE PREGNANCY IN RELATION TO PLACENTAL TISSUE CONCENTRATION

被引:18
作者
LEE, JN [1 ]
GRUDZINSKAS, JG [1 ]
CHARD, T [1 ]
机构
[1] ST BARTHOLOMEWS HOSP,COLL MED,DEPT REPROD PHYSIOL,LONDON EC1,ENGLAND
来源
BRITISH JOURNAL OF OBSTETRICS AND GYNAECOLOGY | 1979年 / 86卷 / 11期
关键词
D O I
10.1111/j.1471-0528.1979.tb10717.x
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
The concentrations of human chorionic gonadotrophin (hCG), human placental lactogen (hPL), pregnancy specific β1 glycoprotein (SP1), ferritin (PP2) and placental protein 5 (PP5) were examined in maternal serum and placental tissue in early and late pregnancy. The circulating concentration of hPL, SP1, and PP5 were higher during late pregnancy than early pregnancy, that of hCG lower, and ferritin (PP2) levels showed no difference. Placental tissue levels of hPL and SP1 were higher in late pregnancy, hCG levels lower, and ferritin (PP2) and PP5 showed no change. The ratio of the concentration in maternal serum to that in placental tissue increased during pregnancy for all proteins with the exception of ferritin. It is proposed that the mechanism of secretion of trophoblast specific proteins varies widely and that this should be taken into account in the clinical interpretation of circulating levels in the mother. Copyright © 1979, Wiley Blackwell. All rights reserved
引用
收藏
页码:888 / 890
页数:3
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