DISTRIBUTION AND URINARY EXCRETION OF FUROSEMIDE IN RAT

Using 35S‐labeled furosemide, the distribution and excretion of furosemide was investigated. Emphasis was placed upon the possibility of accumulation of the compound resulting from daily administration. The excretion and distribution of furosemide and/or metabolites (expressed as furosemide) were determined at various time intervals after termination of dosing. Of the tissues studied, the level of furosemide was the highest in the liver and kidney. At the termination of drug administration, furosemide levels in liver and kidney of single‐dose animals were not significantly different from levels observed in repeatedly treated rats; however, 10 days later the retention of furosemide was significantly greater in the repeatedly treated rats. The results of the excretion studies indicated, as did the distribution data, that furosemide may have accumulated in repeatedly treated animals. Copyright © 1969 Wiley‐Liss, Inc., A Wiley Company