A GENERAL SCHEME FOR THE INCORPORATION OF PHARMACOKINETICS IN LOW-DOSE RISK-ESTIMATION FOR CHEMICAL CARCINOGENESIS - EXAMPLE - VINYL-CHLORIDE

被引：39

作者：

ANDERSON, MW ^{[1
]}

HOEL, DG ^{[1
]}

KAPLAN, NL ^{[1
]}

机构：

[1] NIEHS,BIOMETRY BRANCH,RES TRIANGLE PK,NC 27709

来源：

TOXICOLOGY AND APPLIED PHARMACOLOGY | 1980年 / 55卷 / 01期

关键词：

D O I：

10.1016/0041-008X(80)90231-8

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

引用

页码：154 / 161

页数：8

共 12 条

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[2]

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[3]

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[4] RISK OF ANGIOSARCOMA IN WORKERS EXPOSED TO VINYL-CHLORIDE AS PREDICTED FROM STUDIES IN RATS [J].

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PARK, CN .

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[5] RESOLUTION OF DOSE-RESPONSE TOXICITY DATA FOR CHEMICALS REQUIRING METABOLIC ACTIVATION - EXAMPLE VINYL CHLORIDE [J].

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PARK, CN .

TOXICOLOGY AND APPLIED PHARMACOLOGY, 1978, 44 (03) :581-591

[6] LOW-DOSE-RATE EXTRAPOLATION OF DATA FROM ANIMAL CARCINOGENICITY EXPERIMENTS - ANALYSIS OF A NEW STATISTICAL TECHNIQUE [J].

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CRUMP, KS .

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[7] ESTIMATION OF RISKS OF IRREVERSIBLE, DELAYED TOXICITY [J].

HOEL, DG ;

GAYLOR, DW ;

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SAFFIOTTI, U ;

SCHNEIDERMAN, MA .

JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH, 1975, 1 (01) :133-151

[8]

HOEL DG, 1979, 1 COLD SPRING HARB L, P135

[9] CARCINOGENICITY BIOASSAYS OF VINYL-CHLORIDE - CURRENT RESULTS [J].

MALTONI, C ;

LEFEMINE, G .

ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 1975, 246 (JAN31) :195-218

[10]

Watanabe P G, 1977, J Environ Pathol Toxicol, V1, P147

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