PROBING THE STRUCTURE OF FOLDING INTERMEDIATES

被引：91
作者：
EVANS, PA [1 ]
RADFORD, SE [1 ]
机构：
[1] UNIV OXFORD,NEW CHEM LAB,OXFORD OX1 3QT,ENGLAND
来源：
CURRENT OPINION IN STRUCTURAL BIOLOGY | 1994年 / 4卷 / 01期
关键词：
D O I：
10.1016/S0959-440X(94)90066-3
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The description of protein folding mechanisms in terms of the structures of well defined, partially folded intermediates is a major objective in structural biology. Despite the fleeting existence of intermediates and the fact that their structures are unlikely to be uniquely defined, significant advances in our understanding of protein folding pathways have been made in the last year based on a variety of physical methods.
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页码：100 / 106
页数：7
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