INTERSPECIES VARIATIONS IN RESPONSE TO TOPICAL APPLICATION OF SELECTED ZINC-COMPOUNDS

被引：27
作者：
LANSDOWN, ABG
机构：
[1] Charing Cross and Westminster Medical School, Department of Comparative Biology, London
来源：
FOOD AND CHEMICAL TOXICOLOGY | 1991年 / 29卷 / 01期
关键词：
D O I：
10.1016/0278-6915(91)90063-D
中图分类号：
TS2 [食品工业];
学科分类号：
0832 ;
摘要：
The dermal irritancy of six zinc compounds was examined in three animal models. In open patch tests involving five daily applications, zinc chloride (1% aqueous solution) was severely irritant in rabbit, guinea-pig and mouse tests, inducing epidermal hyperplasia and ulceration; aqueous zinc acetate (20%) was slightly less irritant. Zinc oxide (20% suspension dilute Tween 80), zinc sulphate (1% aqueous solution) and zinc pyrithione (20% suspension) were not overly irritant, but induced a marginal epidermal hyperplasia and increased hair growth. Zinc undecylenate (20% suspension) was not irritant. Epidermal irritancy in these studies is related to the interaction of zinc ion with epidermal keratin. The compounds studied were not consistently bacteriostatic in the three species tested.
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页码：57 / 64
页数：8
相关论文
共 42 条
[1]   LACK OF ACCELERATION OF HEALING WITH ZINC SULFATE [J].
BARCIA, PJ .
ANNALS OF SURGERY, 1970, 172 (06) :1048-&
[2]   DIURNAL CYCLE EPIDERMAL MITOTIC DURATION AND ITS RELATION TO CHALONE AND ADRENALIN [J].
BULLOUGH, WS ;
LAURENCE, EB .
EXPERIMENTAL CELL RESEARCH, 1966, 43 (02) :343-+
[3]   ZINC SULPHATE AND BEDSORES [J].
COHEN, C .
BRITISH MEDICAL JOURNAL, 1968, 2 (5604) :561-&
[4]   RECURRENT ZINC-RESPONSIVE DERMATOSIS IN A SIBERIAN [J].
DEGRYSE, AD ;
FRANSEN, J ;
VANCUTSEM, J ;
OOMS, L .
JOURNAL OF SMALL ANIMAL PRACTICE, 1987, 28 (08) :721-&
[5]  
Draize JH, 1944, J PHARMACOL EXP THER, V82, P377
[6]   ACRODERMATITIS AND ACQUIRED ZINC-DEFICIENCY [J].
ECKER, RI ;
SCHROETER, AL .
ARCHIVES OF DERMATOLOGY, 1978, 114 (06) :937-939
[7]   THE EFFECT AND MODE OF ACTION OF ZINC PYRITHIONE ON CELL-GROWTH .2. INVIVO STUDIES [J].
GIBSON, WT ;
HARDY, WS ;
GROOM, MH .
FOOD AND CHEMICAL TOXICOLOGY, 1985, 23 (01) :103-&
[8]   EFFECTS OF SYSTEMIC ZINC SUPPLEMENTS ON STRENGTH OF HEALING INCISED WOUNDS IN NORMAL RATS [J].
GROUNDWATER, W ;
MACLEOD, IB .
BRITISH JOURNAL OF SURGERY, 1970, 57 (03) :222-+
[9]  
HALLBOOK T, 1972, LANCET, V2, P780
[10]  
HALLMANS G, 1978, SCANDINAVIAN J PLAST, V10, P177
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