CHROMOSOMAL MAPPING OF THE HUMAN INTERLEUKIN-1 RECEPTOR ANTAGONIST GENE (IL-1RN) AND ISOLATION OF SPECIFIC YAC CLONES

被引：8

作者：

STEINKASSERER, A ^{[1
]}

SPURR, NK ^{[1
]}

SIM, RB ^{[1
]}

机构：

[1] ICRF,CLARE HALL LAB,POTTERS BAR EN6 3LD,HERTS,ENGLAND

来源：

AGENTS AND ACTIONS | 1993年 / 38卷

关键词：

D O I：

10.1007/BF01991137

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Using a panel of somatic rodent-human cell hybrids, we show that the interleukin-1 receptor antagonist gene (IL-1RN) maps to the long arm of human chromosome 2. Linkage studies permitted the regional localization of this gene to band q14-21. This is the same region in which the IL-1alpha and IL-1beta genes are localized. Three yeast artificial chromosome (YAC) clones containing the IL-1RN gene were isolated, and these will be used for further characterization of this chromosome 2 region.

引用

页码：C59 / C60

页数：2

共 3 条

[1] BLOCKING IL-1 - INTERLEUKIN-1 RECEPTOR ANTAGONIST INVIVO AND INVITRO [J].

DINARELLO, CA ;

THOMPSON, RC .

IMMUNOLOGY TODAY, 1991, 12 (11) :404-410

[2] LENGTH VARIATION WITHIN INTRON-2 OF THE HUMAN IL-1 RECEPTOR ANTAGONIST PROTEIN GENE (IL1RN) [J].

STEINKASSERER, A ;

KOELBLE, K ;

SIM, RB .

NUCLEIC ACIDS RESEARCH, 1991, 19 (18) :5095-5095

[3] THE HUMAN IL-1 RECEPTOR ANTAGONIST GENE (IL1RN) MAPS TO CHROMOSOME-2Q14-Q21, IN THE REGION OF THE IL-1-ALPHA AND IL-1-BETA LOCI [J].

STEINKASSERER, A ;

SPURR, NK ;

COX, S ;

JEGGO, P ;

SIM, RB .

GENOMICS, 1992, 13 (03) :654-657

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