DISTRIBUTION OF BINDING-SITES FOR I-125-LABELED ALPHA-BUNGAROTOXIN IN NORMAL AND DEAFFERENTED ANTENNAL LOBES OF MANDUCA-SEXTA

被引：122

作者：

HILDEBRAND, JG ^{[1
]}

HALL, LM ^{[1
]}

OSMOND, BC ^{[1
]}

机构：

[1] MIT, DEPT BIOL 16711, CAMBRIDGE, MA 02139 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1979年 / 76卷 / 01期

关键词：

D O I：

10.1073/pnas.76.1.499

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

125I-Labeled α-bungarotoxin has been used to determine the distribution of putative acetylcholine receptors in normal and chronically deafferented antennal lobes in the brain of the moth Manduca sexta. Toxin-binding sites are confined to synaptic regions in the neuropil of normal lobes and to rudiments of these regions in deafferented lobes. These findings suggest that receptors can develop in the insect central nervous system independently of normal synaptic influences.

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页码：499 / 503

页数：5

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