Sensitivity of the circadian system to evening bright light in preschool-age children

被引:47
作者
Akacem, Lameese D. [1 ]
Wright, Kenneth P., Jr. [2 ]
LeBourgeois, Monique K. [1 ]
机构
[1] Univ Colorado, Sleep & Dev Lab, Dept Integrat Physiol, Boulder, CO 80309 USA
[2] Univ Colorado, Dept Integrat Physiol, Sleep & Chronobiol Lab, Boulder, CO 80309 USA
来源
PHYSIOLOGICAL REPORTS | 2018年 / 6卷 / 05期
关键词
Circadian; light; melatonin suppression; preschool children; sleep;
D O I
10.14814/phy2.13617
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
Although the light-induced melatonin suppression response is well characterized in adults, studies examining the dynamics of this effect in children are scarce. The purpose of this study was to quantify the magnitude of evening light-induced melatonin suppression in preschool-age children. Healthy children (n=10; 7 females; 4.3 +/- 1.1years) participated in a 7-day protocol. On days 1-5, children followed a strict sleep schedule. On day 6, children entered a dim light environment (<15 lux) for 1-h before providing salivary samples every 20- to 30-min from the afternoon until 50-min after scheduled bedtime. On day 7, subjects remained in dim light conditions until 1-h before bedtime, at which time they were exposed to a bright light stimulus (similar to 1000 lux) for 1-h and then re-entered dim light conditions. Saliva samples were obtained before, during, and after bright light exposure and were time anchored to samples taken the previous evening. We found robust melatonin suppression (87.6 +/- 10.0%) in response to the bright light stimulus. Melatonin levels remained attenuated for 50-min after termination of the light stimulus (P<0.008). Furthermore, melatonin levels did not return to 50% of those observed in the dim light condition 50-min after the light exposure for 7/10 children. Our findings demonstrate a robust light-induced melatonin suppression response in preschool-age children. These findings have implications for understanding the role of evening light exposure in the development of evening settling difficulties and may serve as experimental evidence to support recommendations regarding light exposure and sleep hygiene practices in early childhood.
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页数:10
相关论文
共 59 条
[11]   Evening use of light-emitting eReaders negatively affects sleep, circadian timing, and next-morning alertness [J].
Chang, Anne-Marie ;
Aeschbach, Daniel ;
Duffy, Jeanne F. ;
Czeisler, Charles A. .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2015, 112 (04) :1232-1237
[12]   Human responses to bright light of different durations [J].
Chang, Anne-Marie ;
Santhi, Nayantara ;
St Hilaire, Melissa ;
Gronfier, Claude ;
Bradstreet, Dayna S. ;
Duffy, Jeanne F. ;
Lockley, Steven W. ;
Kronauer, Richard E. ;
Czeisler, Charles A. .
JOURNAL OF PHYSIOLOGY-LONDON, 2012, 590 (13) :3103-3112
[13]   The human circadian system adapts to prior photic history [J].
Chang, Anne-Marie ;
Scheer, Frank A. J. L. ;
Czeisler, Charles A. .
JOURNAL OF PHYSIOLOGY-LONDON, 2011, 589 (05) :1095-1102
[14]   Age, lens transmittance, and the possible effects of light on melatonin suppression [J].
Charman, WN .
OPHTHALMIC AND PHYSIOLOGICAL OPTICS, 2003, 23 (02) :181-187
[15]   Human Adolescent Phase Response Curves to Bright White Light [J].
Crowley, Stephanie J. ;
Eastman, Charmane I. .
JOURNAL OF BIOLOGICAL RHYTHMS, 2017, 32 (04) :334-344
[16]   Increased Sensitivity of the Circadian System to Light in Early/Mid-Puberty [J].
Crowley, Stephanie J. ;
Cain, Sean W. ;
Burns, Angus C. ;
Acebo, Christine ;
Carskadon, Mary A. .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2015, 100 (11) :4067-4073
[17]  
CZEISLER CA, 1981, PHOTOCHEM PHOTOBIOL, V34, P239
[18]   POSTURE INFLUENCES MELATONIN CONCENTRATIONS IN PLASMA AND SALIVA IN HUMANS [J].
DEACON, S ;
ARENDT, J .
NEUROSCIENCE LETTERS, 1994, 167 (1-2) :191-194
[19]  
Drijfhout WJ, 1996, J NEUROCHEM, V66, P748
[20]   Microdialysis reveals dynamics of coupling between noradrenaline release and melatonin secretion in conscious rats [J].
Drijfhout, WJ ;
vanderLinde, AG ;
deVries, JB ;
Grol, CJ ;
Westerink, BHC .
NEUROSCIENCE LETTERS, 1996, 202 (03) :185-188