ACTIVITY IN SALINE OF PHTHALYLATED OR SUCCINYLATED DERIVATIVES OF MYCOBACTERIAL WATER-SOLUBLE ADJUVANT

被引：4

作者：

AUDIBERT, F ^{[1
]}

CHEDID, L ^{[1
]}

机构：

[1] INST PASTEUR, CNRS, GRP RECH 31, F-75724 PARIS 15, FRANCE

来源：

INFECTION AND IMMUNITY | 1976年 / 14卷 / 06期

关键词：

D O I：

10.1128/IAI.14.6.1263-1268.1976

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A water-soluble fraction (WSA) of the cell wall can substitute for mycobacterial cells in Freund complete adjuvant. However, when WSA is administered [to mice] in saline instead of in a water-in-oil emulsion, its adjuvant activity is very weak, and under certain experimental conditions it can even inhibit the humoral immune response. After treatment of phthalic or succinic anhydride the adjuvant activity of WSA was markedly changed, since high levels of circulating antibodies were produced when these derivatives were administered with an antigen in an aqueous medium. The antigenic determinants of WSA were modified and acylated WSA had no tuberculin-like activity.

引用

页码：1263 / 1268

页数：6

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