TRP-1 EXPRESSION CORRELATES WITH EUMELANOGENESIS IN HUMAN PIGMENT-CELLS IN CULTURE

被引：69

作者：

DELMARMOL, V

ITO, S

JACKSON, I

VACHTENHEIM, J

BERR, P

GHANEM, G

MORANDINI, R

WAKAMATSU, K

HUEZ, G

机构：

[1] UNIV LIBRE BRUXELLES,DEPT MOLEC BIOL,B-1050 BRUSSELS,BELGIUM

[2] FUJITA HLTH UNIV,SCH HYG,TOYOAKE,AICHI,JAPAN

[3] WESTERN HOSP,MRC,HUMAN GENET UNIT,EDINBURGH,SCOTLAND

来源：

FEBS LETTERS | 1993年 / 327卷 / 03期

关键词：

BROWN; TYROSINASE; MELANOGENESIS; HUMAN;

D O I：

10.1016/0014-5793(93)81010-W

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We have investigated the relationship in human cultured normal and malignant melanocytes between the accumulation of mRNAs encoding tyrosinase and tyrosinase-related protein-1 (TRP-1), the activity of tyrosinase and the presence of melanin. Tyrosinase mRNA correlates with tyrosinase activity and with the presence of pheomelanin, eumelanin or both melanin types. In contrast TRP-1 mRNA is only detectable in cells containing eumelanin, which suggests a role for TRP-1 in the eumelanin synthesis pathway.

引用

页码：307 / 310

页数：4

共 20 条

[1] THE HUMAN HOMOLOG OF THE MOUSE BROWN GENE MAPS TO THE SHORT ARM OF CHROMOSOME-9 AND EXTENDS THE KNOWN REGION OF HOMOLOGY WITH MOUSE CHROMOSOME-4 [J].