INTERACTIONS BETWEEN SIALOADENECTOMY AND CAPSAICIN-SENSITIVE AFFERENT-FIBERS ON GASTRIC-ACID SECRETION IN RATS

被引：6
|
作者：
EVANGELISTA, S [1 ]
RENZI, D [1 ]
GUZZI, P [1 ]
MAGGI, CA [1 ]
机构：
[1] UNIV FLORENCE,DEPT CLIN PATHOPHYSIOL,GASTROENTEROL UNIT,I-50100 FLORENCE,ITALY
来源：
LIFE SCIENCES | 1991年 / 48卷 / 07期
关键词：
D O I：
10.1016/0024-3205(91)90549-Q
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
In this study we have investigated the relative influence of capsaicin-sensitive afferents and sialoadenectomy on gastric acid secretion. Sialoadenectomized (SALX) rats showed a decrease in gastric acid secretion and an increase in gastric calcitonin gene-related peptide-like immunoreactivity (CGRP-li) as compared to sham-operated animals. Capsaicin pretreatment (50+100 mg kg-1 in two days) markedly decreased gastric CGRP-li in both sham and SALX-operated rats and increased acid concentration and output only in SALX animals. In this latter case the concomitant absence of two potent endogenous antisecretory agents (CGRP and epidermal growth factor; EGF) may contribute to the observed hypersecretion. Gastric content of vasoactive intestinal polypeptide (VIP)-li was unaffected in SALX and capsaicin-treated rats. Capsaicin-sensitive afferents and EGF contained in the salivary glands may interact in the regulation of the gastric acid secretion.
引用
收藏
页码：PL37 / PL41
页数：5
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