INTERACTIONS BETWEEN SIALOADENECTOMY AND CAPSAICIN-SENSITIVE AFFERENT-FIBERS ON GASTRIC-ACID SECRETION IN RATS

被引：6

作者：

EVANGELISTA, S ^{[1
]}

RENZI, D ^{[1
]}

GUZZI, P ^{[1
]}

MAGGI, CA ^{[1
]}

机构：

[1] UNIV FLORENCE,DEPT CLIN PATHOPHYSIOL,GASTROENTEROL UNIT,I-50100 FLORENCE,ITALY

来源：

LIFE SCIENCES | 1991年 / 48卷 / 07期

关键词：

D O I：

10.1016/0024-3205(91)90549-Q

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

In this study we have investigated the relative influence of capsaicin-sensitive afferents and sialoadenectomy on gastric acid secretion. Sialoadenectomized (SALX) rats showed a decrease in gastric acid secretion and an increase in gastric calcitonin gene-related peptide-like immunoreactivity (CGRP-li) as compared to sham-operated animals. Capsaicin pretreatment (50+100 mg kg-1 in two days) markedly decreased gastric CGRP-li in both sham and SALX-operated rats and increased acid concentration and output only in SALX animals. In this latter case the concomitant absence of two potent endogenous antisecretory agents (CGRP and epidermal growth factor; EGF) may contribute to the observed hypersecretion. Gastric content of vasoactive intestinal polypeptide (VIP)-li was unaffected in SALX and capsaicin-treated rats. Capsaicin-sensitive afferents and EGF contained in the salivary glands may interact in the regulation of the gastric acid secretion.

引用

页码：PL37 / PL41

页数：5

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