INTERACTION INVIVO BETWEEN STRONG CLOSELY SPACED CONSTITUTIVE PROMOTERS

被引：37

作者：

HAUSLER, B ^{[1
]}

SOMERVILLE, RL ^{[1
]}

机构：

[1] PURDUE UNIV,DEPT BIOCHEM,W LAFAYETTE,IN 47907

来源：

JOURNAL OF MOLECULAR BIOLOGY | 1979年 / 127卷 / 03期

关键词：

D O I：

10.1016/0022-2836(79)90335-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

By genetic recombination procedures we have constructed strains of Escherichia coli K12 wherein up to three strong promoters ostensibly could function simultaneously and independently in the formation of messenger RNA molecules which specify tryptophan synthase. In all such multiple promoter cases, enzyme production falls short of the levels predicted from summing the measured contributions of each promoter taken singly. Possible molecular explanations for this phenomenon, which can produce apparent interferences in enzyme production as high as 42%, are considered. © 1979.

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页码：353 / 356

页数：4

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