ELEVATION OF SERUM GROUP-II PHOSPHOLIPASE A(2) LEVELS IN PATIENTS WITH ADVANCED CANCER

被引：62

作者：

YAMASHITA, S ^{[1
]}

OGAWA, M ^{[1
]}

SAKAMOTO, K ^{[1
]}

ABE, T ^{[1
]}

ARAKAWA, H ^{[1
]}

YAMASHITA, J ^{[1
]}

机构：

[1] KUMAMOTO UNIV,SCH MED,DEPT SURG 2,KUMAMOTO 860,JAPAN

来源：

CLINICA CHIMICA ACTA | 1994年 / 228卷 / 02期

关键词：

MEMBRANE-ASSOCIATED PHOSPHOLIPASE A(2); CANCER; CELL LINE;

D O I：

10.1016/0009-8981(94)90280-1

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

To investigate the role of group II phospholipase A(2) (M-PLA(2)) in cancer, we examined M-PLA(2) serum levels in 170 pre-operative patients with various cancers and found elevated levels in 49% of them. M-PLA(2) serum levels were significantly higher in patients with tumor stages T2-4, N1, M1 and stages II to IV than in T1, NO, MO and stage I tumors, respectively. In all nine post-operative patients tested, M-PLA(2) decreased 14 days after tumor resection and reduced to normal levels in 4 patients. Six of 16 carcinoma cell lines (37.5%) spontaneously secreted M-PLA(2) into the culture supernatant despite the absence of IL-6 and IL-1 in 5 of the 6 lines. These results demonstrate that M-PLA(2) produced by cancer cells may contribute, at least in part, to the elevation of serum M-PLA(2) levels observed in cancer patients.

引用

页码：91 / 99

页数：9

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