CHRONIC TREATMENT WITH MIF-1 PREVENTS THE PAINFUL STIMULI THRESHOLD ELEVATION INDUCED BY NEONATAL HANDLING IN MICE

被引：14

作者：

DAMORE, A ^{[1
]}

PIERETTI, S ^{[1
]}

CHIAROTTI, F ^{[1
]}

LOIZZO, A ^{[1
]}

机构：

[1] IST SUPER SANITA,VIALE REGINA ELENA 299,I-00161 ROME,ITALY

来源：

PEPTIDES | 1991年 / 12卷 / 06期

关键词：

MIF-1; CHRONIC TREATMENT; NEONATAL HANDLING; BEHAVIORAL EFFECTS;

D O I：

10.1016/0196-9781(91)90209-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Chronic postnatal stressful handling results in a hyposensitivity to thermal nociceptive stimuli. This phenomenon is strongly affected by manipulations of the opioid system. In the present experiment, we report that chronic treatment with MIF-1 during the neonatal period prevents the behavioral alterations induced by handling while it is completely ineffective if injected acutely before antinociceptive testing by the tail flick test at 45 days of life.

引用

页码：1291 / 1294

页数：4

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