No Polymorphism in Plasmodium falciparum K13 Propeller Gene in Clinical Isolates from Kolkata, India

被引：14

作者：

Chatterjee, Moytrey ^{[1
]}

Ganguly, Swagata ^{[1
,2
]}

Saha, Pabitra ^{[1
,3
]}

Bankura, Biswabandhu ^{[4
]}

Basu, Nandita ^{[5
]}

Das, Madhusudan ^{[4
]}

Guha, Subhasish K. ^{[6
]}

Maji, Ardhendu K. ^{[1
]}

机构：

[1] Calcutta Sch Trop Med, Dept Microbiol, Protozool Unit, Kolkata 700073, India

[2] NRS Med Coll, Dept Microbiol, Kolkata 700014, India

[3] APC Roy Govt Coll, Dept Zool, Siliguri 734010, W Bengal, India

[4] Univ Calcutta, Dept Zool, Ballygunge Sci Coll, Kolkata 700019, India

[5] Calcutta Sch Trop Med, Kolkata 700073, India

[6] Calcutta Sch Trop Med, Dept Trop Med, Kolkata 700073, India

来源：

JOURNAL OF PATHOGENS | 2015年 / 2015卷

关键词：

D O I：

10.1155/2015/374354

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Molecular markers associated with artemisinin resistance in Plasmodium falciparum are yet to be well defined. Recent studies showed that polymorphisms in K13 gene are associated with artemisinin resistance. The present study was designed to know the pattern of polymorphisms in propeller region of K13 gene among the clinical isolates collected from urban Kolkata after five years of ACT implementation. We collected 59 clinical isolates from urban Kolkata and sequenced propeller region of K13 gene in 51 isolates successfully. We did not find any mutation in any isolate. All patients responded to the ACT, a combination of artesunate + sulphadoxine-pyrimethamine. The drug regimen is still effective in the study area and there is no sign of emergence of resistance against artemisinin as evidenced by wild genotype of K13 gene in all isolates studied.

引用

页数：4

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