SYNTHESIS AND BIOLOGICAL EVALUATION OF SOME HALO-SUBSTITUTED AND TRIFLUOROMETHYL-SUBSTITUTED PHENYLCEPHALOSPORINS AND PHENYLDEACETOXYCEPHALOSPORINS

被引：0

作者：

KOBAL, E

VALENCIC, M

TISLER, V

VITEZIC, N

JAPELJ, M

机构：

[1] EDVARD KARDELJ UNIV, FAC NAT SCI & TECHNOL, YU-61000 LJUBLJANA, SLOVENIA

[2] RES & DEV INST KRKA, PHARMACEUT & CHEM WORKS, YU-68000 NOVO MESTO, SLOVENIA

[3] EDVARD KARDELJ UNIV, DEPT CHEM & CHEM TECHNOL, YU-61000 LJUBLJANA, SLOVENIA

来源：

ACTA PHARMACEUTICA | 1992年 / 42卷 / 01期

关键词：

D O I：

暂无

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The synthesis and in vitro antibacterial activity of some halo- and trifluoromethyl-substituted phenylcephalosporins and substituted phenyldeacetoxycephalosporins are described. The dilution method [minimal inhibitory concentration, MIC (mu-g ml-1)] was used to test the synthesized compounds. We were interested in the following questions: 1. Is this type of substances highly active only against Gram-positive organisms? 2. Which halogen and which positions of halogen are especially favorable?

引用

页码：59 / 67

页数：9

共 12 条

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