ADRENAL DEMEDULLATION AND PERIPHERAL 6-OHDA ADMINISTRATION IN THE RABBIT - EFFECTS ON BODY-WEIGHT, GENERAL ACTIVITY AND CARDIOVASCULAR RESPONSIVITY

被引：4
作者：
JOSEPH, J
BOGGAN, W
POWELL, DA
机构：
[1] MED UNIV S CAROLINA,DEPT PSYCHIAT,CHARLESTON,SC 29403
[2] VET ADM HOSP,MED CTR,NEUROSCI LAB,COLUMBIA,SC 29201
[3] UNIV S CAROLINA,COLUMBIA,SC 29208
来源：
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR | 1979年 / 10卷 / 06期
关键词：
6-OHDA; Activity; Blood pressure; Heart rate; Rabbits;
D O I：
10.1016/0091-3057(79)90061-3
中图分类号：
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号：
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要：
Two experiments were undertaken to determine the effects of systemic 6-hydroxydopamine (6-OHDA) administration and adrenal enucleation on body weight, brain and heart norepinephrine, general activity, and cardiovascular responsivity in the rabbit. 6-Hydroxydopamine produced long lasting, dose related decreases in baseline blood pressure (BP) and in pressor responses following electric shock. Partial reversal of the BP changes was observed in nonenucleated animals tested 20 days after 6-OHDA administration but not in enucleated animals tested 5, 10 or 20 days post-injection or in control animals tested 5, 10 or 15 days after vehicle injection. Although 6-OHDA administration produced transient weight loss and activity decrements, no long term weight or activity changes were observed. © 1979.
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页码：875 / 881
页数：7
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