DELAYED DAMAGE OF STRIATAL INTERNEURONS AFTER CEREBRAL-ISCHEMIA IN THE GERBIL

被引：7
作者：
ARAKI, T
KATO, H
LIU, XH
ITOYAMA, Y
KOGURE, K
KATO, K
机构：
[1] FDN BRAIN & NERVE DIS,KUMAGAYA,JAPAN
[2] INST NEUROPATHOL,KUMAGAYA,JAPAN
[3] AICHI PREFECTURAL COLONY,INST DEV RES,DEPT BIOCHEM,KASUGAI,AICHI 48003,JAPAN
来源：
NEUROSCIENCE LETTERS | 1994年 / 176卷 / 01期
关键词：
CEREBRAL ISCHEMIA; PARVALBUMIN; MAP2; IMMUNOHISTOCHEMISTRY; STRIATAL INTERNEURON; GERBIL;
D O I：
10.1016/0304-3940(94)90860-5
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Immunohistochemical changes of striatal interneurons in the gerbil were investigated 1 h-7 days after 10 min cerebral ischemia. Marked reduction of parvalbumin-immunoreactive interneurons was seen in the striatum from 24 h after ischemia. MAP2 (microtubule-associated protein 2) immunoreactivity markedly decreased in striatal neurons 5 h after ischemia but was unaffected in interneurons. Thereafter, a severe loss of MAP2 immunoreactivity in the interneurons was found 48 h and 7 days after ischemia. The results demonstrate that transient cerebral ischemia can cause a loss of parvalbumin and MAP2 immunoreactivity in interneurons in the dorsolateral striatum in a delayed fashion as compared with a rapid loss of striatal neurons.
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收藏
页码：17 / 20
页数：4
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