METALLOPORPHYRINS INHIBIT NITRIC OXIDE-DEPENDENT CGMP FORMATION IN-VIVO

被引：106

作者：

LUO, DS ^{[1
]}

VINCENT, SR ^{[1
]}

机构：

[1] UNIV BRITISH COLUMBIA,DEPT PSYCHIAT,DIV NEUROL SCI,VANCOUVER V6T 1Z3,BC,CANADA

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY-MOLECULAR PHARMACOLOGY SECTION | 1994年 / 267卷 / 03期

关键词：

CEREBELLUM; MICRODIALYSIS; METALLOPORPHYRINS; NITRIC OXIDE SYNTHASE; GUANYLYL CYCLASE; CGMP;

D O I：

10.1016/0922-4106(94)90149-X

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Sodium nitroprusside produced a dose-dependent increase in extracellular levels of cGMP in the cerebellar cortex in vivo. This was independent of nitric oxide synthase activity. The metalloporphyrins zinc-protoporphyrin-IX, tin-protoporphyrin-IX and zinc-deuteroporphyrin-IX,2,4-bis glycol prevented the increase in cGMP in the cerebellar cortex produced by sodium nitroprusside. At high doses, tin-protoporphyrin-IX also decreased the basal extracellular levels of cGMP. These drugs had no effect on nitric oxide synthase activity. We conclude that the neuropharmacological effects of metalloporphyrins may result from their direct inhibition of soluble guanylyl cyclase, rather than from an effect on carbon monoxide synthesis.

引用

页码：263 / 267

页数：5

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