IMMUNIZATION OF LIPASE AGAINST ACETALDEHYDE EMERGING IN ACYL TRANSFER-REACTIONS FROM VINYL-ACETATE

被引：81

作者：

BERGER, B ^{[1
]}

FABER, K ^{[1
]}

机构：

[1] GRAZ UNIV TECHNOL,INST ORGAN CHEM,STREMAYRGASSE 16,A-8010 GRAZ,AUSTRIA

来源：

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS | 1991年 / 17期

关键词：

D O I：

10.1039/c39910001198

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Immobilization of Candida cylindracea lipase by covalent linkage involving the epsilon-amino residues of lysine leads to a five-fold increase of selectivity which is entirely preserved against deactivation caused by acetaldehyde, an unavoidable by-product in acyl transfer reactions with vinyl acetate.

引用

页码：1198 / 1200

页数：3

共 22 条

[1] ENZYMATIC ESTER HYDROLYSIS AND SYNTHESIS - 2 APPROACHES TO CYCLOALKANE DERIVATIVES OF HIGH ENANTIOMERIC PURITY [J].

ADER, U ;

BREITGOFF, D ;

KLEIN, P ;

LAUMEN, KE ;

SCHNEIDER, MP .

TETRAHEDRON LETTERS, 1989, 30 (14) :1793-1796

[2]

AKIYAMA A, 1987, CHEM BRIT, V23, P645

[3] ENZYMATIC ACYLATION USING ACID ANHYDRIDES - CRUCIAL REMOVAL OF ACID [J].

BERGER, B ;

RABILLER, CG ;

KONIGSBERGER, K ;

FABER, K ;

GRIENGL, H .

TETRAHEDRON-ASYMMETRY, 1990, 1 (08) :541-546

[4] ANHYDRIDES AS ACYLATING AGENTS IN LIPASE-CATALYZED STEREOSELECTIVE ESTERIFICATION OF RACEMIC ALCOHOLS [J].

BIANCHI, D ;

CESTI, P ;

BATTISTEL, E .

JOURNAL OF ORGANIC CHEMISTRY, 1988, 53 (23) :5531-5534

[5] NEW SYNTHETIC CARRIERS FOR ENZYMES [J].

BURG, K ;

MAUZ, O ;

NOETZEL, S ;

SAUBER, K .

ANGEWANDTE MAKROMOLEKULARE CHEMIE, 1988, 157 :105-121

[6] GENERAL-ASPECTS AND OPTIMIZATION OF ENANTIOSELECTIVE BIOCATALYSIS IN ORGANIC-SOLVENTS - THE USE OF LIPASES [J].

CHEN, CS ;

SIH, CJ .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH, 1989, 28 (06) :695-707

[7] QUANTITATIVE-ANALYSES OF BIOCHEMICAL KINETIC RESOLUTIONS OF ENANTIOMERS [J].

CHEN, CS ;

FUJIMOTO, Y ;

GIRDAUKAS, G ;

SIH, CJ .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1982, 104 (25) :7294-7299

[8] ENZYMATIC RESOLUTION OF STERICALLY DEMANDING BICYCLO[3.2.0]HEPTANES - EVIDENCE FOR A NOVEL HYDROLASE IN CRUDE PORCINE PANCREATIC LIPASE AND THE ADVANTAGES OF USING ORGANIC MEDIA FOR SOME OF THE BIOTRANSFORMATIONS [J].

COTTERILL, IC ;

SUTHERLAND, AG ;

ROBERTS, SM ;

GROBBAUER, R ;

SPREITZ, J ;

FABER, K .

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1991, (06) :1365-1368

[9] ENZYMATIC-REACTIONS IN ORGANIC-SYNTHESIS .2. ESTER INTERCHANGE OF VINYL ESTERS [J].

DEGUEILCASTAING, M ;

DEJESO, B ;

DROUILLARD, S ;

MAILLARD, B .

TETRAHEDRON LETTERS, 1987, 28 (09) :953-954

[10] ACETALDEHYDE ADDUCTS WITH PROTEINS - BINDING OF [C-14]-LABELED ACETALDEHYDE TO SERUM-ALBUMIN [J].

DONOHUE, TM ;

TUMA, DJ ;

SORRELL, MF .

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1983, 220 (01) :239-246

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