DROSOPHILA HAS A TWITCHIN TITIN-RELATED GENE THAT APPEARS TO ENCODE PROJECTIN

被引：89

作者：

AYMESOUTHGATE, A ^{[1
]}

VIGOREAUX, J ^{[1
]}

BENIAN, G ^{[1
]}

PARDUE, ML ^{[1
]}

机构：

[1] EMORY UNIV,SCH MED,DEPT PATHOL,ATLANTA,GA 30322

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1991年 / 88卷 / 18期

关键词：

MUSCLE PROTEINS; IMMUNOGLOBULIN SUPERFAMILY; SEQUENCE EVOLUTION;

D O I：

10.1073/pnas.88.18.7973

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The sequences of twitchin and titin identify a superfamily of muscle proteins whose functions are not completely understood. In spite of their shared structural features, twitchin and titin appear to differ in function. Genetic and molecular evidence suggests that twitchin has a regulatory role in muscle contraction, whereas it has been proposed that titin has a structural function. We report here that Drosophila has a single-copy gene containing the two-motif amino acid sequence pattern that characterizes twitchin and titin. This gene appears to encode projectin, a muscle protein that is thought to play a structural role in asynchronous flight muscle but may have a role like that of twitchin in synchronous muscle. Thus Drosophila appears to be a case where the apparently diverged functions of twitchin and titin are encoded by a single gene.

引用

页码：7973 / 7977

页数：5

共 29 条

[1] LOCUS 67B OF DROSOPHILA-MELANOGASTER CONTAINS 7, NOT 4, CLOSELY RELATED HEAT-SHOCK GENES [J].