THIN-LAYER CHROMATOGRAPHY AND DENSITOMETRY IN DRUG ASSAY - COMPARISON OF METHODS FOR MONITORING VALPROIC ACID IN PLASMA

被引：10
作者：
CORTI, P
CENNI, A
CORBINI, G
DREASSI, E
MURRATZU, C
CARICCHIA, AM
机构：
[1] Dipartimento Farmaco Chimico Tecnologico, Università degli Studi di Siena, 53100 Siena
来源：
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS | 1990年 / 8卷 / 05期
关键词：
anti-epileptic agents; TLC densitometry; valproic acid;
D O I：
10.1016/0731-7085(90)80071-V
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
A thin-layer chromatographic (TLC) method is described for the assay of the anti-epileptic drug, valproic acid, in plasma. The use of high-performance (HPTLC) plates gave sensitive detection limits (4.87 μg ml-1) for derivatives of valproic acid and the reproducibility on the same or different plates was good. Comparison with high-performance liquid chromatography showed a similar performance of plate and column. © 1990.
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收藏
页码：431 / 436
页数：6
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