HEMATOPORPHYRIN DIETHERS .5. PLASMA-PROTEIN BINDING AND PHOTOSENSITIZING EFFICIENCY

被引：16
作者：
KONGSHAUG, M
RIMINGTON, C
EVENSEN, JF
PENG, Q
MOAN, J
机构：
来源：
INTERNATIONAL JOURNAL OF BIOCHEMISTRY | 1990年 / 22卷 / 10期
关键词：
D O I：
10.1016/0020-711X(90)90110-O
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
1. 1. Binding of added hematoporphyrin (HP) ethers to human plasma proteins and lipoproteins has been investigated by ultracentifugation. 2. 2. The binding to low density lipoproteins (LDL) has been discussed in terms of photosensitized tumor growth delay of tumors and HPLC-retention time, i.e. degree of polarity. 3. 3. The LDL-binding data show a uniform relationship to sensitizing efficiency and degree of polarity, the only exception being HP-diamyl ether. No such uniform relationship exists for less related dyes, such as HP, tetraphenylporphyrin tetrasulfonate and HP-dimethyl ether. © 1990.
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页码：1127 / 1131
页数：5
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