INFLUENCE OF TESTICULAR MICROANATOMY ON THE POTENTIAL GENETIC DOSE FROM INTERNALLY DEPOSITED PU-239 CITRATE IN CHINESE-HAMSTER, MOUSE, AND MAN

被引：18
作者：
BROOKS, AL
DIEL, JH
MCCLELLAN, RO
机构：
来源：
RADIATION RESEARCH | 1979年 / 77卷 / 02期
关键词：
D O I：
10.2307/3575141
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The localization, retention, and microdistribution of 239Pu citrate in the testes of the Chinese hamster were determined. Testicular morphometric measurements were made in adult mice and Chinese hamsters as well as in aged, adult, and immature humans. Calculations based on these morphometric measurements and a nonuniform microdistribution of plutonium indicated that the radiation dose to spermatogonia of man was less than that predicted from a uniform distribution of activity. This contrasts with the enhanced dose to the spermatogonia in mouse and Chinese hamsters produced by the unique microanatomy and nonuniform deposition of plutonium in the testes of rodents. Levels of 239Pu which induced marked life shortening and increased cancer incidence caused no significant increase in the frequency of mitotic chromosome aberrations in spermatogonia.
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页码：292 / 302
页数：11
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