THE ASYMMETRIC-SYNTHESIS OF (-)-CAPTOPRIL UTILIZING THE IRON CHIRAL AUXILIARY [ETA-5-C5H5)FE(CO)(PPH3)]

被引：29

作者：

BASHIARDES, G ^{[1
]}

DAVIES, SG ^{[1
]}

机构：

[1] DYSON PERRINS LAB,S PARKS RD,OXFORD OX1 3QY,ENGLAND

来源：

TETRAHEDRON LETTERS | 1987年 / 28卷 / 45期

关键词：

D O I：

10.1016/S0040-4039(00)96782-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Stereoselective alkylation of (R)-[(η5-C5H5)Fe(CO)(PPh3)COCH2CH3] with bromomethyl-t-butyl sulphide, followed by oxidative decomplexation in the presence of L-proline t-butyl ester gave, after deprotection, (-)-Captopril enantiomerically and diastereomerically pure in an overall yield of 59%. © 1987.

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页码：5563 / 5564

页数：2

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