ATTENUATION OF THE GAMMA-BUTYROLACTONE-INDUCED INCREASE IN DOPA ACCUMULATION BY CHRONIC ETHANOL ADMINISTRATION

被引：13
作者：
LILJEQUIST, S
ENGEL, J
机构：
[1] Department of Pharmacology, University of Göteborg
来源：
JOURNAL OF NEURAL TRANSMISSION | 1979年 / 46卷 / 03期
关键词：
γ-butyrolactone; apomorphine; central dopamine neurons; Chronic ethanol;
D O I：
10.1007/BF01250785
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
The effect of γ-butyrolactone (GBL) on the accumulation of dopa after inhibition of aromatic amino acid decarboxylase was studied in rats following chronic treatment with ethanol. The GBL-induced dopa accumulation was significantly decreased in ethanol-treated rats. With the increased duration of the ethanol treatment this effect appears to be more marked in the limbic forebrain. It is suggested that chronic ethanol treatment may produce a decreased sensitivity of central GABA receptors. © 1979 Springer-Verlag.
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页码：195 / 204
页数：10
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