ARE EUKARYOTIC MICROORGANISMS CLONAL OR SEXUAL - A POPULATION-GENETICS VANTAGE

被引：333

作者：

TIBAYRENC, M

KJELLBERG, F

ARNAUD, J

OURY, B

BRENIERE, SF

DARDE, ML

AYALA, FJ

机构：

[1] CNRS,F-34033 MONTPELLIER,FRANCE

[2] CHU PURPAN,CTR RECH POLYMORPH GENET POPULAT HUMAINES,CNRS,F-31300 TOULOUSE,FRANCE

[3] UNIV GRENOBLE 1,FAC MED,CNRS,URA 1344,PARASITOL MYCOL MED & MOLEC LAB,F-38706 LA TRONCHE,FRANCE

[4] CHU DUPUYTREN,SERV PARASITOL,F-87042 LIMOGES,FRANCE

[5] UNIV CALIF IRVINE,DEPT ECOL & EVOLUT BIOL,IRVINE,CA 92717

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1991年 / 88卷 / 12期

关键词：

PARASITIC PROTOZOA; FUNGI; MALARIA; LEISHMANIASIS; TOXOPLASMA;

D O I：

10.1073/pnas.88.12.5129

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

We argue that the mode of reproduction of microorganisms in nature can only be decided by population genetic information. The evidence available indicates that many parasitic protozoa and unicellular fungi have clonal rather than sexual population structures, which has major consequences for medical research and practice. Plasmodium falciparum, the agent of malaria, is a special case: the scarce evidence available is contradictory, some suggesting that uniparental lineages may exist in nature. This is puzzling (because P. falciparum is known to have a sexual stage) and poses a challenge that can be readily settled by ascertaining the frequency distribution of genotypes in natural populations.

引用

页码：5129 / 5133

页数：5

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