SYNTHESIS AND PRELIMINARY SCINTIGRAPHIC EVALUATION OF INVIVO DISTRIBUTION OF C-11-HYDROXYUREA-ISOHYDROXYUREA AND CYANATE-C-11

被引：12

作者：

WINSTEAD, MB ^{[1
]}

CHERN, C ^{[1
]}

LIN, TH ^{[1
]}

KHENTIGAN, A ^{[1
]}

LAMB, JF ^{[1
]}

WINCHELL, HS ^{[1
]}

机构：

[1] MEDI PHYS INC,EMERYVILLE,CA 94608

来源：

INTERNATIONAL JOURNAL OF APPLIED RADIATION AND ISOTOPES | 1978年 / 29卷 / 07期

关键词：

D O I：

10.1016/0020-708X(78)90081-9

中图分类号：

TL [原子能技术]; O571 [原子核物理学];

学科分类号：

0827 ; 082701 ;

摘要：

H**1**1CN, produced directly from proton bombardment of 99% N//2-1% H//2 left bracket **1**4N(p, alpha )**1**1C right bracket , was oxidized by KMnO//4 to **1**1C-cyanate which was added to hydroxylamine at minus 5 to 0 degree C to yield a mixture of hydorxyurea and isohydroxyurea. Scintigraphic evaluation of in vivo distribution in a dog following administration of KO**1**1CN showed diffuse whole-body distribution, apparently including brain, with greater activity seen in regions of the heart, liver and kidneys. Similar evaluation of a dog given **1**1C-hydroxyurea/isohydroxyurea showed early localization of activity in the region of the heart which appeared to be due to activity in the myocardium. However, tissue activity measured in rats after administrtion of this material failed to demonstrate concentration in the myocardium.

引用

页码：443 / 447

页数：5

共 10 条

[1] POTASSIUM CYANATE AS AN INHIBITOR OF SICKLING OF ERYTHROCYTES IN-VITRO (UREA/HEMOGLOBIN S/CARBAMYLATED VALINE) [J].