REACTIONS OF BETA-FLUOROVINAMIDINIUM SALT WITH BIFUNCTIONAL HETERO NUCLEOPHILES - A NEW SYNTHETIC ROUTE TO FLUORINATED HETEROCYCLES

被引：32
作者：
SHI, XF
ISHIHARA, T
YAMANAKA, H
GUPTON, JT
机构：
[1] KYOTO INST TECHNOL,DEPT CHEM & MAT TECHNOL,SAKYO KU,KYOTO 606,JAPAN
[2] UNIV CENT FLORIDA,DEPT CHEM,ORLANDO,FL 32816
来源：
TETRAHEDRON LETTERS | 1995年 / 36卷 / 09期
关键词：
D O I：
10.1016/0040-4039(95)00076-O
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
beta-Fluorovinamidinium salt (2), readily prepared from N-(2,3,3-trifluoro-1-propenyl)trimethylammonium iodide (1) and diethylamine, reacted with bifunctional hetero nucleophiles such as amidine and guanidine hydrochlorides in the presence of a base to afford regiospecifically monofluorinated pyrimidines 4 in good yields. The one-pot procedure starting from 1 was applicable for synthesizing heterocyclic compounds 4 in almost comparable yields.
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页码：1527 / 1530
页数：4
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