CHANGES IN TRANSCUTANEOUS OXYGEN PARTIAL-PRESSURE AS AN INDEX OF RESPONSE TO INHALED METHACHOLINE IN ASTHMATIC-PATIENTS

被引：10

作者：

FONTANA, GA ^{[1
]}

CARDELLICCHIO, S ^{[1
]}

CAMICIOTTOLI, G ^{[1
]}

PANUCCIO, P ^{[1
]}

BODDI, V ^{[1
]}

机构：

[1] UNIV FLORENCE,IST PATOL GEN,I-50134 FLORENCE,ITALY

来源：

CHEST | 1993年 / 103卷 / 05期

关键词：

D O I：

10.1378/chest.103.5.1375

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

Bronchoconstriction and hypoxemia have been reported to occur during airway challenges, but the correlation between changes in forced expiratory volume in 1 s (FEV1) and transcutaneous oxygen partial pressure (tcPo2) during methacholine provocation tests has not yet been established (to our knowledge). In 15 symptom-free atopic asthmatic patients and 5 normal subjects, variations in tcPo2 and FEV1 were simultaneously measured during inhalation of doubling methacholine concentrations; the drug concentrations causing a 20 percent decrease in control FEV1 and tcPo2 (PC20FEV1 and PC20tcPo2, respectively) were subsequently calculated. In patients, geometric mean PC20FEV1 and PC20tcPo2 were 1.31 (range, 0.16 to 5.19) and 1.26 (range, 0.29 to 5.82) mg/ml, respectively. In addition, in six patients, methacholine-induced fall in tcPo2 was accompanied by similar changes in arterial Po2. Methacholine inhalation caused no change in tcPo2 or FEV1 in normal subjects. The independent effects of deep breath tests and bronchoconstriction on PC20tcPo2 were studied in five patients challenged on two separate occasions, with and without FEV1 assessment; in these patients, PC20tcPo2 were similar on both the study days. The results indicate that, in asthmatic patients, methacholine-induced bronchoconstriction causes parallel decreases in FEV1 and tcPo2. The tcPo2 monitoring may serve as a tool in the assessment of airway hyperreactivity when active patient's cooperation is scarce.

引用

页码：1375 / 1380

页数：6

共 25 条

[1]

BURKE TV, 1908, CHEST, V96, P752

[2]

CHATHAM M, 1982, AM REV RESPIR DIS, V126, P235

[3] NONINVASIVE ASSESSMENT OF BLOOD-GASES [J].

CLARK, JS ;

VOTTERI, B ;

ARIAGNO, RL ;

CHEUNG, P ;

EICHHORN, JH ;

FALLAT, RJ ;

LEE, SE ;

NEWTH, CJL ;

ROTMAN, H ;

SUE, DY .

AMERICAN REVIEW OF RESPIRATORY DISEASE, 1992, 145 (01) :220-232

[4] BRONCHIAL REACTIVITY TO INHALED HISTAMINE - METHOD AND CLINICAL SURVEY [J].

COCKCROFT, DW ;

KILLIAN, DN ;

MELLON, JJA ;

HARGREAVE, FE .

CLINICAL ALLERGY, 1977, 7 (03) :235-243

[5]

CUSHLEY MJ, 1984, AM REV RESPIR DIS, V129, P380

[6] BLOOD-GAS CHANGES DURING AND AFTER NONSPECIFIC AIRWAY CHALLENGE IN ASTHMATIC AND NORMAL SUBJECTS [J].

DALNEGRO, R ;

ALLEGRA, L .

JOURNAL OF APPLIED PHYSIOLOGY, 1989, 67 (06) :2627-2630

[7] BLOOD-GAS CHANGES IN NONASTHMATIC RHINITIS DURING AND AFTER NONSPECIFIC AIRWAY CHALLENGE [J].

DALNEGRO, RW ;

TURCO, PA ;

ALLEGRA, L .

AMERICAN REVIEW OF RESPIRATORY DISEASE, 1992, 145 (02) :337-339

[8] MILD ISOCAPNIC HYPOXIA ENHANCES THE BRONCHIAL RESPONSE TO METHACHOLINE IN ASTHMATIC SUBJECTS [J].

DENJEAN, A ;

ROUX, C ;

HERVE, P ;

BONNIOT, JP ;

COMOY, E ;

DUROUX, P ;

GAULTIER, C .

AMERICAN REVIEW OF RESPIRATORY DISEASE, 1988, 138 (04) :789-793

[9]

EMPEY DW, 1976, AM REV RESPIR DIS, V113, P131

[10] EFFECT OF DEEP INSPIRATION ON AIRWAY CONDUCTANCE IN SUBJECTS WITH ALLERGIC RHINITIS AND ALLERGIC-ASTHMA [J].

FISH, JE ;

PETERMAN, VI ;

CUGELL, DW .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 1977, 60 (01) :41-46

← 1 2 3 →