AN ANTIPLATELET AGGREGATION PRINCIPLE AND X-RAY STRUCTURAL-ANALYSIS OF CIS-KHELLACTONE DIESTER FROM PEUCEDANUM-JAPONICUM

被引：32
|
作者：
JONG, TT
HWANG, HC
JEAN, MY
WU, TS
TENG, CM
机构：
[1] NATL CHENG KUNG UNIV, DEPT CHEM, TAINAN, TAIWAN
[2] NATL TAIWAN UNIV, COLL MED, INST PHARMACOL, TAIPEI, TAIWAN
来源：
JOURNAL OF NATURAL PRODUCTS | 1992年 / 55卷 / 10期
关键词：
D O I：
10.1021/np50088a002
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Three structurally related khellactone coumarins, 1-3, were isolated from the aerial parts of Peucedanum japonicum (Umbelliferae). Compound 2 was identified as a new coumarin (cis-3'-isovaleryl-4'-senecioylkhellactone) by spectral and chemical analysis. Conformation of the dihydropyrano ring of cis-3',4'-disenecioylkhellactone 13] was elucidated by X-ray crystallographic analysis. These three natural khellactone esters were subjected to the antiplatelet aggregation bioassay where cis-3',4'-diisovalerylkhellactone [1] showed significant activity at 50 mug/ml).
引用
收藏
页码：1396 / 1401
页数：6
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