AN ANTIPLATELET AGGREGATION PRINCIPLE AND X-RAY STRUCTURAL-ANALYSIS OF CIS-KHELLACTONE DIESTER FROM PEUCEDANUM-JAPONICUM

被引：32
|
作者：
JONG, TT
HWANG, HC
JEAN, MY
WU, TS
TENG, CM
机构：
[1] NATL CHENG KUNG UNIV, DEPT CHEM, TAINAN, TAIWAN
[2] NATL TAIWAN UNIV, COLL MED, INST PHARMACOL, TAIPEI, TAIWAN
来源：
JOURNAL OF NATURAL PRODUCTS | 1992年 / 55卷 / 10期
关键词：
D O I：
10.1021/np50088a002
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Three structurally related khellactone coumarins, 1-3, were isolated from the aerial parts of Peucedanum japonicum (Umbelliferae). Compound 2 was identified as a new coumarin (cis-3'-isovaleryl-4'-senecioylkhellactone) by spectral and chemical analysis. Conformation of the dihydropyrano ring of cis-3',4'-disenecioylkhellactone 13] was elucidated by X-ray crystallographic analysis. These three natural khellactone esters were subjected to the antiplatelet aggregation bioassay where cis-3',4'-diisovalerylkhellactone [1] showed significant activity at 50 mug/ml).
引用
收藏
页码：1396 / 1401
页数：6
相关论文
共 50 条
  • [31] X-RAY STRUCTURAL-ANALYSIS OF MULTILAYERED CO/NOBLE METAL-FILMS
    YAMANE, H
    MAENO, Y
    KOBAYASHI, M
    MATERIALS TRANSACTIONS JIM, 1995, 36 (06): : 705 - 711
  • [32] X-RAY STRUCTURAL-ANALYSIS OF MOLTEN LIF-KF EQUIMOLAR MIXTURE
    IGARASHI, K
    MUROFUSHI, M
    IWADATE, Y
    MOCHINAGA, J
    OHNO, H
    CHEMISTRY LETTERS, 1985, (06) : 817 - 818
  • [33] X-RAY STRUCTURAL-ANALYSIS IN DI-OXO-URANIUM (VI) COMPLEXES
    GUTBERLET, T
    DREISSIG, W
    LUGER, P
    BECHTHOLD, HC
    BLOCK, D
    KNOECHEL, A
    ZEITSCHRIFT FUR KRISTALLOGRAPHIE, 1986, 174 (1-4): : 69 - 70
  • [34] SYNTHESIS AND X-RAY STRUCTURAL-ANALYSIS OF A DIBENZO[C,F]OXOCANESPIRO DERIVATIVE
    NEIDLEIN, R
    KRAMER, B
    KRIEGER, C
    ZEITSCHRIFT FUR NATURFORSCHUNG SECTION B-A JOURNAL OF CHEMICAL SCIENCES, 1990, 45 (11): : 1577 - 1581
  • [35] SYNTHESIS AND X-RAY CRYSTAL STRUCTURAL-ANALYSIS OF A FULLY UNSATURATED TETRAPHOSPHOLE MACROCYCLE
    DESCHAMPS, E
    RICARD, L
    MATHEY, F
    JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1995, (15) : 1561 - 1561
  • [36] AN X-RAY STRUCTURAL-ANALYSIS OF CESIUM SUBSTITUTION IN THE BARIUM HOLLANDITE PHASE OF SYNROC
    CHEARY, RW
    KWIATKOWSKA, J
    JOURNAL OF NUCLEAR MATERIALS, 1984, 125 (02) : 236 - 243
  • [37] X-RAY STRUCTURAL-ANALYSIS OF DISLOCATION-STRUCTURES IN POLYCRYSTALS BY DISTRIBUTIONS OF MICRODEFORMATIONS
    SELIVANOV, VN
    SMYSLOV, EF
    INDUSTRIAL LABORATORY, 1994, 60 (02): : 110 - 114
  • [38] X-RAY STRUCTURAL-ANALYSIS OF MULTILAYERED CO NOBLE-METAL FILMS
    YAMANE, H
    MAENO, Y
    KOBAYASHI, M
    JOURNAL OF THE JAPAN INSTITUTE OF METALS, 1994, 58 (11) : 1233 - 1238
  • [39] REPRESENTATION AND X-RAY STRUCTURAL-ANALYSIS OF OXOVANADIUM(V)-ETHYL-XANTHATE
    KIEL, G
    SAYIN, H
    GATTOW, G
    ZEITSCHRIFT FUR KRISTALLOGRAPHIE, 1982, 159 (1-4): : 72 - 72
  • [40] TETRAMETHYLCYCLOPENTADIENYLINDIUM(I) AND TETRAMETHYLCYCLOPENTADIENYLTHALLIUM(I) - SYNTHESIS, CHARACTERIZATION AND X-RAY STRUCTURAL-ANALYSIS
    SCHUMANN, H
    KUCHT, H
    KUCHT, A
    GORLITZ, FH
    DIETRICH, A
    ZEITSCHRIFT FUR NATURFORSCHUNG SECTION B-A JOURNAL OF CHEMICAL SCIENCES, 1992, 47 (09): : 1241 - 1248
12345