PREVENTIVE EFFECTS OF A CHINESE HERB MEDICINE (SHO-SAIKO-TO) AGAINST LETHALITY AFTER RECOMBINANT HUMAN TUMOR-NECROSIS-FACTOR ADMINISTRATION IN MICE

被引：17

作者：

SAKAGUCHI, S ^{[1
]}

TUTUMI, E ^{[1
]}

YOKOTA, K ^{[1
]}

FURUSAWA, S ^{[1
]}

SASAKI, K ^{[1
]}

TAKAYANAGI, Y ^{[1
]}

机构：

[1] TOHOKU COLL PHARMACEUT SCI,CANC RES INST,SENDAI,MIYAGI 981,JAPAN

来源：

MICROBIOLOGY AND IMMUNOLOGY | 1991年 / 35卷 / 05期

关键词：

D O I：

10.1111/j.1348-0421.1991.tb01569.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We observed the effects of a chinese herb medicine Sho-saiko-to on the lethal and antitumor activities of recombinant human tumor necrosis factor (rhTNF) administered in mice. Sho-saiko-to was noted to protect the rhTNF-induced lethality in galactosamine-hypersensitized mice, and also Sho-saiko-to pretreated mice was protected against the decrease of rectal temperature after rhTNF administration. On the other hand, there was a remarkable enhancement of antitumor activity of rhTNF by Sho-saiko-to pretreatment. These results suggest that Sho-saiko-to drug may protect mice from severe shock syndrome induced by rhTNF.

引用

页码：389 / 394

页数：6

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