CHRONIC HALOPERIDOL - NEURAL CORRELATES OF MOTOR DISORDERS IN AN INVERTEBRATE MODEL

被引：4

作者：

SAKHAROV, D ^{[1
]}

VORONEZHSKAYA, E ^{[1
]}

NEZLIN, L ^{[1
]}

机构：

[1] DALHOUSIE UNIV,DEPT PHYSIOL & BIOPHYS,HALIFAX B3H 4H7,NS,CANADA

来源：

NEUROREPORT | 1994年 / 5卷 / 06期

关键词：

HALOPERIDOL; MOTOR DISORDER; DOPAMINE DEPLETION; LEECH; HELOBDELLA-STAGNALIS (HIRUDINEA);

D O I：

10.1097/00001756-199402000-00001

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

TO analyse the mechanisms underlying chronic effects of antipsychotic drugs, a simpler invertebrate preparation is proposed. Bathing of leeches for three days in a 1.0 muM aqueous haloperidol (HAL) solution resulted in (i) discoordination of locomotion, including the inability of the Posterior sucker to successfully attach to the substratum, and (ii) transmitter depletion in all putative dopamine (DA) neurones of the sucker and in some, but not all, DA neurones of middle body segments. Both behavioural restoration and cellular DA recovery were observed in disabled animals after bathing in 1.25 nM L-DOPA solution. We conclude that chronic HAL-produced motor disorders are causally related to DA deficiency.

引用

页码：667 / 670

页数：4

共 19 条

[1] QUANTITATIVE LIGHT MICROSCOPIC DEMONSTRATION OF INCREASED PALLIDAL AND STRIATAL MET(5)-ENKEPHALIN-LIKE IMMUNOREACTIVITY IN RATS FOLLOWING CHRONIC TREATMENT WITH HALOPERIDOL BUT NOT WITH CLOZAPINE - IMPLICATIONS FOR THE PATHOGENESIS OF NEUROLEPTIC-INDUCED MOVEMENT-DISORDERS [J].

AUCHUS, AP ;

PICKEL, VM .

EXPERIMENTAL NEUROLOGY, 1992, 117 (01) :17-27

[2]

Baldessarini R J, 1980, Adv Biochem Psychopharmacol, V24, P451

[3] 5-OH-DOPA AND 5-S-CYSTEINYLDOPA - NEW BIOGENIC AMINO-ACIDS IN INVERTEBRATES [J].

CARLBERG, M ;

LAXMYR, L ;

ROSENGREN, E ;

ELOFSSON, R .

COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-PHARMACOLOGY TOXICOLOGY & ENDOCRINOLOGY, 1982, 73 (01) :23-25

[4] ENZYMATIC 5-HYDROXYLATION OF L-DOPA BY A TYROSINASE ISOLATED FROM THE SEA-ANEMONE METRIDIUM-SENILE [J].

CARLBERG, M ;

JERGIL, B ;

LINDBLADH, C ;

ROSENGREN, E .

GENERAL PHARMACOLOGY, 1984, 15 (04) :301-307

[5]

CHIODO LA, 1983, J NEUROSCI, V3, P1607

[6] METHODOLOGICAL APPROACH TO RAPID AND SENSITIVE MONOAMINE HISTOFLUORESCENCE USING A MODIFIED GLYOXYLIC-ACID TECHNIQUE - SPG METHOD [J].

DELATORRE, JC ;

SURGEON, JW .

HISTOCHEMISTRY, 1976, 49 (02) :81-93

[7] IS EXPERIMENTAL CATALEPSY PROPERLY MEASURED [J].

FERRE, S ;

GUIX, T ;

PRAT, G ;

JANE, F ;

CASAS, M .

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 1990, 35 (04) :753-757

[8] SEROTONIN ANALOG SELECTIVELY ABLATES IDENTIFIED NEURONS IN THE LEECH EMBRYO [J].

GLOVER, JC ;

KRAMER, AP .

SCIENCE, 1982, 216 (4543) :317-319

[9]

GLOVER JC, 1987, J NEUROSCI, V7, P581

[10]

KABOTYANSKI EA, 1989, J EVOL BIOCHEM PHYS, V25, P295

← 1 2 →