LOCALIZATION OF EXPERIMENTAL BRAIN-TUMORS IN MRI BY GADOLINIUM PORPHYRIN

被引：0
作者：
BOCKHORST, K [1 ]
ELS, T [1 ]
KOHNO, K [1 ]
HOEHNBERLAGE, M [1 ]
机构：
[1] MAX PLANCK INST NEUROL RES, DEPT EXPTL NEUROL, GLEUELER STR 50, D-50931 COLOGNE, GERMANY
来源：
ACTA NEUROCHIRURGICA | 1994年
关键词：
PARAMAGNETIC CONTRAST AGENT; METALLOPORPHYRIN-T(2)-WEIGHTED IMAGING; GLIOMA;
D O I：
暂无
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
The contrast between edema and F98 glioma in rat brain was distinctly enhanced in T2-weighted MRI (TE 130 ms, TR 3 s) by intraperitoneal injection of the synthetic gadolinium-porphyrin complex, GdTPPS. The T1 relaxation time of the gliomas was selectively shortened by about 50% from 1339 +/- 109 ms to 628 +/-106 ms, and the T2 relaxation time was shortened by about 35% from 86 +/- 6 ms to 57 +/- 5 ms. The relaxation times of normal tissues under investigation (cortex, corpus callosum, temporal muscle, ventricles) were unaltered. Therefore, GdTPPS-application causes F98 gliomas to appear hyperintense in T1-weighted MRI and hypointense in T2-weighted MRI.
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页码：347 / 349
页数：3
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