VOLATILE ANESTHETICS SELECTIVELY ALTER [H-3] RYANODINE BINDING TO SKELETAL AND CARDIAC RYANODINE RECEPTORS

被引：32

作者：

CONNELLY, TJ ^{[1
]}

ELHAYEK, R ^{[1
]}

RUSY, BF ^{[1
]}

CORONADO, R ^{[1
]}

机构：

[1] UNIV WISCONSIN,DEPT PHYSIOL,MADISON,WI 53792

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1992年 / 186卷 / 01期

关键词：

D O I：

10.1016/S0006-291X(05)80850-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The effect of clinical concentrations of volatile anesthetics on ryanodine receptors of cardiac and skeletal muscle sarcoplasmic reticulum was evaluated using [3H]ryanodine binding. At 2 volume percent, halothane and enflurane stimulated binding to cardiac SR by 238% and 204%, respectively, while isoflurane had no effect. In contrast, halothane and enflurane had no effect on [3H]ryanodine binding to skeletal ryanodine receptors, while isoflurane produced a significant stimulation. These results suggest that volatile anesthetics interact in a site-specific manner with ryanodine receptors of cardiac or skeletal muscle to effect Ca2+ release-channel gating. © 1992 Academic Press, Inc.

引用

页码：595 / 600

页数：6

共 18 条

[1] COMPARATIVE STUDY OF EFFECTS OF 5 GENERAL ANESTHETICS ON MYOCARDIAL CONTRACTILITY - ISOMETRIC CONDITIONS [J].