EXPERIMENTAL TESTICULAR GERM-CELL TUMOROGENESIS IN MOUSE STRAINS WITH AND WITHOUT SPONTANEOUS TUMORS DIFFERS FROM DEVELOPMENT OF GERM-CELL TUMORS OF THE ADULT HUMAN TESTIS

被引：26
作者：
WALT, H
OOSTERHUIS, JW
STEVENS, LC
机构：
[1] DR DANIEL DEN HOED CANC CTR,ROTTERDAM,NETHERLANDS
[2] JACKSON LAB,BAR HARBOR,ME 04609
来源：
INTERNATIONAL JOURNAL OF ANDROLOGY | 1993年 / 16卷 / 04期
关键词：
CARCINOMA-IN-SITU; EMBRYONAL CARCINOMA; HUMAN; MOUSE; SEMINOMA; TERATOMA; TESTICULAR GERM CELL TUMOR; TUMOROGENESIS;
D O I：
10.1111/j.1365-2605.1993.tb01190.x
中图分类号：
R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
摘要：
The aim of this study was to undertake a morphological analysis of the earliest stages of experimentally induced (by genital ridge grafting) germ cell tumours in mouse strains with (129/Sv-ter) and without (MA) spontaneous tumorogenesis. Genital ridges from fetuses aged 12 or 13 days from 129/Sv-ter and MA were transplanted into the testes of adult 129/Sv-ter. The results show clearly that experimentally induced carcinoma-in-situ in mouse testes differs considerably from its human counterpart, found in patients with and without testicular germ cell tumours, and considered to be the precursor for all kinds of germ cell tumours of the adult testis apart from spermatocytic seminoma. The results indicate that development of testicular germ cell tumours is different in man and the mouse.
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页码：267 / 271
页数：5
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