INHIBITORY EFFECT OF MELATONIN ON PLATELET ACTIVATION-INDUCED BY COLLAGEN AND ARACHIDONIC-ACID

被引：35

作者：

KORNBLIHTT, LI ^{[1
]}

FINOCCHIARO, L ^{[1
]}

MOLINAS, FC ^{[1
]}

机构：

[1] UNIV BUENOS AIRES,INST INVEST MED ALFRED LANARI,FAC MED,DONATO ALVAREZ 3150,RA-1427 BUENOS AIRES,ARGENTINA

来源：

JOURNAL OF PINEAL RESEARCH | 1993年 / 14卷 / 04期

关键词：

MELATONIN; ARACHIDONIC ACID; COLLAGEN; PLATELET AGGREGATION; SEROTONIN RELEASE;

D O I：

10.1111/j.1600-079X.1993.tb00501.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Melatonin, an indolamine synthesized in the pineal gland, is known to have antiprostanoid activity. The inhibition of platelet aggregation induced by melatonin has been proposed to take place through the cyclooxygenase pathway. In the present study, we found that melatonin has a marked inhibitory effect on collagen, arachidonic acid (AA), adenosine diphosphate (ADP), epinephrine, and A23187-induced aggregation in platelet-rich plasma. On the other hand, using metrizamide-filtered platelets resuspended in Tyrode's buffer, melatonin fails to suppress AA-induced platelet aggregation and C-14-5-HT release. Under the same conditions, melatonin inhibits collagen-induced platelet activation; however, the addition of threshold doses of AA (0.3 mM) abrogates this effect. These studies suggest that melatonin also inhibits platelet function at a stage preceding the cyclooxygenase-dependent pathway.

引用

页码：184 / 191

页数：8

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