A STABILITY-INDICATING HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHIC ASSAY FOR NICOTINE IN TRANSDERMAL PATCHES

被引：12
作者：
CARLISLE, MR
CHICOINE, ML
WYGANT, MB
机构：
[1] Analytical Chemistry Department, Pharmetrix Corporation, Menlo Park
来源：
INTERNATIONAL JOURNAL OF PHARMACEUTICS | 1992年 / 80卷 / 2-3期
关键词：
NICOTINE; DOSAGE FORM ANALYSIS; STABILITY; HPLC; TRANSDERMAL PATCH;
D O I：
10.1016/0378-5173(92)90280-F
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
This report describes a rapid, precise, stability-indicating method to analyze nicotine as a raw material or in transdermal dosage forms using high-performance liquid chromatography (HPLC) with ultraviolet (UV) detection. The method uses a new multi-phase polymeric column which allows separation by a combination of reversed-phase and ion-exchange chromatography. The method was characterized with respect to specificity, linearity, accuracy, and precision.
引用
收藏
页码：227 / 242
页数：16
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