LIPOSOMES CONTAINING LIPID-A - A POTENT NONTOXIC ADJUVANT FOR A HUMAN MALARIA SPOROZOITE VACCINE

被引：49

作者：

ALVING, CR

RICHARDS, RL

机构：

[1] Department of Membrane Biochemistry, Walter Reed Army Institute of Research, Washington, DC

来源：

IMMUNOLOGY LETTERS | 1990年 / 25卷 / 1-3期

关键词：

Adjuvant; Endotoxin; Lipid A; Liposome; Malaria; Plasmodium falciparum; Vaccine;

D O I：

10.1016/0165-2478(90)90127-C

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Liposomes containing lipid A have been developed as adjuvants for inducing humoral immunity to synthetic antigens containing repeat sequence epitopes from the circumsporozoite protein of Plasmodium falciparum. Preclinical studies demonstrated that liposomes containing lipid A and encapsulated antigen could overcome immunosuppression observed with antigen alone. When liposomes containing lipid A were adsorbed with aluminium hydroxide (alum), further stimulation of humoral immunity against encapsulated antigen was observed in animals. In the presence of huge doses of liposomal lipid A pyrogenicity was not observed and adjuvant activity was enhanced. A phase I human clinical trial has been initiated utilizing a vaccine containing a synthetic recombinant antigen and monophosphoryl lipid A in liposomes and nonliposomal alum as a further adjuvant. Preliminary results confirm that the vaccine lacks significant acute toxicity in humans and causes very strong specific humoral immunity against the appropriate epitopes of the target antigen. © 1990.

引用

页码：275 / 280

页数：6

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