Acquisition of resistance to androgen deprivation therapy in salivary duct carcinoma: A case report

被引：1

作者：

Wasano, Koichiro ^{[1
,2
]}

Sakurai, Kouhei ^{[3
]}

Kawasaki, Taiji ^{[2
]}

Kusafuka, Kimihide ^{[4
]}

Kasahara, Masao ^{[5
]}

Kondo, Naoki ^{[3
]}

Inada, Ken-ichi ^{[3
]}

Ogawa, Kaoru ^{[1
]}

机构：

[1] Keio Univ, Sch Med, Dept Otolaryngol Head & Neck Surg, Tokyo, Japan

[2] Japanese Red Cross Shizuoka Hosp, Dept Otolaryngol, Shizuoka, Japan

[3] Fujita Hlth Univ, Sch Med, Dept Diagnost Pathol 2, Nagoya, Aichi, Japan

[4] Shizuoka Canc Ctr, Div Pathol, Shizuoka, Japan

[5] Japanese Red Cross Shizuoka Hosp, Dept Diagnost Pathol, Shizuoka, Japan

来源：

RARE TUMORS | 2018年 / 10卷

基金：

日本学术振兴会;

关键词：

Salivary duct carcinoma; androgen deprivation therapy; androgen receptor; forkhead box A1; immunohistochemistry;

D O I：

10.1177/2036361318798867

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Salivary duct carcinoma is a relatively rare salivary cancer, and most cases are androgen receptor -positive. Salivary duct carcinoma growth is suggested to be androgen dependent, which can reportedly be controlled by androgen deprivation therapy. However, the effectiveness and underlying molecular mechanisms of androgen deprivation therapy for salivary duct carcinoma remain unknown. We report a salivary duct carcinoma case (65-year-old man) arising from the parotid gland with metastasis to the neck lymph nodes and lungs. Androgen deprivation therapy was performed according to the same protocol for prostate cancer treatment. Expression levels of androgen receptor and FOXA1 (forkhead box A1) were immunohistochemically analyzed before and after androgen deprivation therapy. Although the tumor volume was partially diminished during the first 3 months, acquired resistance to androgen deprivation therapy occurred. FOXA1 was not detected in parotid gland after androgen deprivation therapy, whereas androgen receptor expression was positive. FOXA1 expression might be related to acquired androgen deprivation therapy resistance in salivary duct carcinoma.

引用

页数：5

共 18 条

[1] FOXA1: a transcription factor with parallel functions in development and cancer [J].

Bernardo, Gina M. ;

Keri, Ruth A. .

BIOSCIENCE REPORTS, 2012, 32 (02) :113-130

[2] Molecular Characterization of Apocrine Salivary Duct Carcinoma [J].

Chiosea, Simion I. ;

Williams, Lindsay ;

Griffith, Christopher C. ;

Thompson, Lester D. R. ;

Weinreb, Ilan ;

Bauman, Julie E. ;

Luvison, Alyssa ;

Roy, Somak ;

Seethala, Raja R. ;

Nikiforova, Marina N. .

AMERICAN JOURNAL OF SURGICAL PATHOLOGY, 2015, 39 (06) :744-752

[3] Comprehensive Molecular Characterization of Salivary Duct Carcinoma Reveals Actionable Targets and Similarity to Apocrine Breast Cancer [J].

Dalin, Martin G. ;

Desrichard, Alexis ;

Katabi, Nora ;

Makarov, Vladimir ;

Walsh, Logan A. ;

Lee, Ken-Wing ;

Wang, Qingguo ;

Armenia, Joshua ;

West, Lyndsay ;

Dogan, Snjezana ;

Wang, Lu ;

Ramaswami, Deepa ;

Ho, Alan L. ;

Ganly, Ian ;

Solit, David B. ;

Berger, Michael F. ;

Schultz, Nikolaus D. ;

Reis-Filho, Jorge S. ;

Chan, Timothy A. ;

Morris, Luc G. T. .

CLINICAL CANCER RESEARCH, 2016, 22 (18) :4623-4633

[4] FOXA1 Promotes Tumor Progression in Prostate Cancer and Represents a Novel Hallmark of Castration-Resistant Prostate Cancer [J].

Gerhardt, Josefine ;

Montani, Matteo ;

Wild, Peter ;

Beer, Marc ;

Huber, Fabian ;

Hermanns, Thomas ;

Muentener, Michael ;

Kristiansen, Glen .

AMERICAN JOURNAL OF PATHOLOGY, 2012, 180 (02) :848-861

[5] The mutational landscape of lethal castration-resistant prostate cancer [J].

Grasso, Catherine S. ;

Wu, Yi-Mi ;

Robinson, Dan R. ;

Cao, Xuhong ;

Dhanasekaran, Saravana M. ;

Khan, Amjad P. ;

Quist, Michael J. ;

Jing, Xiaojun ;

Lonigro, Robert J. ;

Brenner, J. Chad ;

Asangani, Irfan A. ;

Ateeq, Bushra ;

Chun, Sang Y. ;

Siddiqui, Javed ;

Sam, Lee ;

Anstett, Matt ;

Mehra, Rohit ;

Prensner, John R. ;

Palanisamy, Nallasivam ;

Ryslik, Gregory A. ;

Vandin, Fabio ;

Raphael, Benjamin J. ;

Kunju, Lakshmi P. ;

Rhodes, Daniel R. ;

Pienta, Kenneth J. ;

Chinnaiyan, Arul M. ;

Tomlins, Scott A. .

NATURE, 2012, 487 (7406) :239-243

[6] Cooperativity and equilibrium with FOXA1 define the androgen receptor transcriptional program [J].

Jin, Hong-Jian ;

Zhao, Jonathan C. ;

Wu, Longtao ;

Kim, Jung ;

Yu, Jindan .

NATURE COMMUNICATIONS, 2014, 5

[7] Prostate cancer progression after androgen deprivation therapy: mechanisms of castrate resistance and novel therapeutic approaches [J].

Karantanos, T. ;

Corn, P. G. ;

Thompson, T. C. .

ONCOGENE, 2013, 32 (49) :5501-5511

[8] Salivary duct carcinoma with rhabdoid features: a salivary counterpart of pleomorphic lobular carcinoma of the breast [J].

Kusafuka, Kimihide ;

Kawasaki, Takuya ;

Maeda, Matsuyoshi ;

Yamanegi, Koji ;

Baba, Satoshi ;

Ito, Yohei ;

Inagaki, Hiroshi ;

Nakajima, Takashi .

HISTOPATHOLOGY, 2017, 70 (02) :164-173

[9] Clinical activity of androgen deprivation therapy in patients with metastatic/relapsed androgen receptor-positive salivary gland cancers [J].

Locati, Laura D. ;

Perrone, Federica ;

Cortelazzi, Barbara ;

Lo Vullo, Salvatore ;

Bossi, Paolo ;

Dagrada, Gianpaolo ;

Quattrone, Pasquale ;

Bergamini, Cristiana ;

Potepan, Paolo ;

Civelli, Enrico ;

Fallai, Carlo ;

Pilotti, Silvana ;

Licitra, Lisa .

HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK, 2016, 38 (05) :724-731

[10] Clinicopathological significance of androgen receptor, HER2, Ki-67 and EGFR expressions in salivary duct carcinoma [J].

Masubuchi, Tatsuo ;

Tada, Yuichiro ;

Maruya, Shin-ichiro ;

Osamura, Yoshiyuki ;

Kamata, Shin-etsu ;

Miura, Kouki ;

Fushimi, Chihiro ;

Takahashi, Hideaki ;

Kawakita, Daisuke ;

Kishimoto, Seiji ;

Nagao, Toshitaka .

INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY, 2015, 20 (01) :35-44

← 1 2 →